The fixed dose combination (FDC) of Glipizide (a sulfonylurea that exerts its hypoglycemic effect by stimulating insulin release from pancreatic ß-cells) and Metformin (an antihyperglycemic agent that reduces glucose absorption from the gastointestinal tract and gluconeogenesis and enhances insulin sensitivity by increasing peripheral glucose uptake and utilisation) is used in the treatment for type 2 diabetes mellitus when either drug alone does not improve glycaemic control.
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Glipizide 5 mg + Metformin Hydrochloride 500 mg Tablet – 10 Tabs
Price: Rs. 6.80
Ingredients: Glipizide 5 mg + Metformin Hydrochloride 500 mg
Packing: 10 Tabs/Strip
Dosage: As directed By the Physician.
Precautions: Hypoglycaemia, stress, elderly, thyroid impairment, monitor blood-glucose concentration and renal function regularly.
Side Effects: Gastrointestinal upsets, diarrhoea, nausea, allergic skin reactions, leucopenia, thrombocytopenia, agranulocytosis, hyponatraemia, jaundice, haemolytic anaemia, pancytopenia, anorexia, diarrhoea, weight loss, flatulence, occasional metallic taste, weakness, hypoglycaemia, rash, malabsorption of vitamin, hypoglycaemia in presence of renal or hepatic damage and alcohol, lactic acidosis in presence of renal failure and alcoholism.
Contraindications: Hypersensitivity, type 2 diabetes mellitus, ketoacidosis, severe renal or hepatic insufficiency, diabetic coma, cardiac failure, recent myocardial infarction, congestive heart failure, insulin-independent diabetes mellitus Severe infection, acute or chronic metabolic acidosis with or without coma, stress, trauma, severe impairment of thyroid function, dehydration & acute or chronic alcoholism, pregnancy, lactation.
Storage Conditions: Store it at room temperature and in an airtight container. Keep away from light and children.